Martinez, Rosa

62-year-old with MSI-H stage IIIC colon adenocarcinoma (T4aN2b), R0 resection. Evaluate adjuvant immunotherapy with pembrolizumab (KEYNOTE-177 extrapolation) vs. standard FOLFOX x 3 months (IDEA collaboration). No prior systemic therapy. ECOG 1, no autoimmune history.

Organ preservation strategy in low rectal cancer with clinical complete response to TNT.

Organ preservation strategy in low rectal cancer with clinical complete response to TNT.

Clinical complete response — watch-and-wait protocol eligibility vs. TME surgery.

Lateral lymph node involvement — role of extended lateral node dissection.

Total neoadjuvant therapy (TNT) sequencing — induction chemo then chemoRT vs. chemoRT then consolidation.

Lateral lymph node involvement — role of extended lateral node dissection.

Lateral lymph node involvement — role of extended lateral node dissection.

Clinical complete response — watch-and-wait protocol eligibility vs. TME surgery.

Organ preservation strategy in low rectal cancer with clinical complete response to TNT.